M.I.T Application for MBA Program †Example Essay

M.I.T Application for MBA Program †Example Essay Free Online Research Papers M.I.T Application for MBA Program Example Essay 1. Clarify how the MIT Sloan MBA Program’s center around advancement will assist you with accomplishing your profession objectives. I generally recall my expired dad continually lamenting his failure to make change. My dad has instructed me that despite the fact that you might be in front of others by strolling, you are still behind in light of the fact that the others are running. My late dad dealt with the xxx Corporation. In 19xx, He couldn't instantly get ready for the new progression of westernization into Korea, for example, the firm’s data framework, westernization of employees’corporate culture; affirmation of the trade guild, new ordered customer’s appearance, and westernization of the assembling. My dad who had dealt with the firm for a long time with dynamic exertion was confronted with misfortune. At long last, his enterprise was to be excused. Alongside his disappointments, he contributed his works of musings to numerous spots. His compositions stressed that a firm that has not experienced change is destined to be a firm that will undoubtedly come up short. My destiny has consistently been to turn into an incredible agent in light of the fact that since the time my youth days, my dad gave perpetual talks concerning a businessman’s mentality. Before my dad died, he left me a message saying, â€Å"the key to a firm’s endurance is innovation.† I will prize his words for eternity. From my late father’s extraordinary impact, I chose to work for xxx upon graduation from undergrad contemplates. While utilized at xxx, I generally remembered the conceivable outcomes of progress and advancement of my work, the firm’s approaches, and current authoritative issues. I convinced the administrators and the top officials, who were stuck on the idea of conventional dynamic systems, face the requirement for advancement by tolerating the trade guild, through conversations and arrangements with my contributed endeavors into expanding profitability. I additionally proposed for the ‘xxx Project’ with key plan to the CEO administrators who were just happy with the fixed salary of nonstop OEM creation. I was assessed and supplemented that the proposition not just carried incredible open doors for the firm to solely make and build up the brand in itself, however an extraordinary open door for the firm to investigate the outside market. From that point, I made another activity to enhancing a large portion of the ventures, for example, hierarchical cutting back, transferal of workers, renewal of tyranny in the administration, appropriation of the ERP framework, and representative preparing for acquiring data, that xxx was after for 18 months since 19xx. I played out these errands healthil y. In spite of the fact that there were numerous issues and numerous who contradicted my proposition for the firm’s development, xxx had an extraordinary basic vision as far as making the firm’s brand in itself and regarding investigating the outside market without precedent for a long time. At the point when I left the organization, there were numerous representatives who were happy to confront the adjustments in business condition all the more emphatically with more noteworthy future vision for the organization. I firmly accept that advancement and inventiveness are significant apparatuses for the 21st century agent. So as to make due in the business world, a firm ought to have the option to change quickly as per the 21st century howdy tech data society of the Internet. In the event that a firm can't alter under such conditions of innovative, the firm can't endure. To turn out to be such a businessperson who can rapidly adjust to these changes, I picked Sloan. Sloan†™s program will empower me to turn into an agent who sees the significance of advancement and administration in the business world. All the more significantly, I accept that Sloan will give me the sort of hardware to move forward in the field of key arranging and showcasing, authoritative plan and change the executives. 2. Depict a circumstance where you presented or potentially oversaw change in an association. Disclose to us how you affected others in an association (business, school, extracurricular movement) and remark on the expert as well as close to home ascribes you used to do that and how these characteristics (an others) may be critical to the accomplishment of your vocation objectives. How would you expect the Sloan School to promote the improvement of these qualities? The most critical improvement that I have made while utilized at xxx was the ‘xxx Project’, which started in February of 19xx, to build up a vital arrangement so as to turn into a worldwide venture, for example, xxx or xxx. xxx that started to create the xxx 21 years back set up the task dependent on the conventional example of the OEM send out. The executive of xxx improvement who had worked for the organization for more than 9 years was negative in making the company’s brand and the assessment of the larger part was that such a venture was too hazardous to even consider producing an item in rivalry with worldwide brands. In spite of the negative feelings around me, I presented the proposition for the xxx and I demanded that xxx make its’ own image picture and challenge the worldwide market. Since x outside organizations, for example, xxx and xxx hold over xx% of the residential market up to 19xx, it is difficult to make the company’s brand name and create innovation later on if the item doesn't create or if the organization keeps on building up the item dependent on the OEM framework. There was likewise a likelihood that even our involved market in the residential market would be denied from those outside organizations. In view of these realities, I demanded innovation collaboration with xxx that brags xx years greatness, creating innovation, making circulation directs and auxiliaries in the industrialized nations including the U.S., and engaging in the worldwide market vivaciously. My report welcomed on numerous discussions about the practicality and the speculation standpoint for 10 months of cutting edge xxx advancement process. At the point when the CEO administrators upheld my proposition, the firm chose to spread out the xxx advancement process for x years and take its’ brand abroad with a key aim. I discovered that a gifted representative ought to have precise judgment with obvious assets and have clear vision for future turn of events. One of the basic factors that drove the firm to deliberately contend in the worldwide market was that my â€Å"xxx†for 4 months, had the option to strike down the entirety of the negative suppositions with my particular information and nitty grit ty methodology. This experience has urged me to proceed with my investigations in an American doctoral level college so as to learn progressively point by point systematic methodology and increase the information behind powerful administration technique. Sloan has all the significant necessities to satisfy my requirements. I unequivocally accept that Strategic Management and Consulting Track of Sloan have assorted assets for businesspeople, for example, innovative work, fund, human asset the board, and showcasing. These significant assets will empower me to accomplish my objective to turning into a CEO of an enterprise. Program of Sloan gives both business enterprise and initiative. I unequivocally accept that Sloan is the best master's level college of business for me just as future representatives. Introductory letter Since I had worked in the xxx branch of xxx, whose yearly pay was $xx million in 19xx, my serious issue was an absence of information in Finance and Management. Upon graduation from undergrad examines, I was utilized in the Management Planning Team. Since I didn't have the foundation in business organization from studying xxx Literature in undergrad, I understood the trouble in getting a handle on the idea of general organization matters, promoting examination, and setting up the short and long haul showcasing plan. At the point when I took an interest later on improvement of xxx and deals venture for 10 months that started in February 19xx, I understood that I was unequipped for effectively playing out my obligations as an Assistant Manager with 8 staff individuals for a task in which the organization intensely relied on. It was then that I had acknowledged what uncommon ability was expected to turn into a fruitful supervisor. For example, while breaking down xxx, xxx’s mecha nical bit of leeway and promoting systems, I understood the significance of picking up Marketing Research and Strategy. I likewise understood the significance of Financial Management and Corporate Financial Policies when arranging deals and promoting systems for the future deals of xxx and techniques for expanding our market. Through these encounters, I turned out to be emphatically roused to applying to your school. In the event that I am given the chance, I might want to examine Corporate Finance and Financial Strategy. In my circumstance that I should return to the xxx, and join the supervisory group, without the information on account, I couldn't effectively deal with the organization and be a clumsy agent. I might want to concentrate my examinations on subjects identifying with Entrepreneurship and Marketing. I accept that I am able to be serious among your understudies since I have earned an authentication of Accounting and Finance,sponsored by the xxx. Alongside this fundamental foundation, I am as of now contemplating Finance as an alumni understudy at the xxx University Business School. Sloan is top decision for two fundamental reasons. As a matter of first importance, Sloan offers assorted courses for a specialist who needs development and administration that are not offered at the xxx University. Second explanation is the numerous preferences that can be offered from the area of your school, with overall serious partnerships assembled in New York and Boston zones. Upon graduation from the Sloan School, I intend to be the most agent individual at xxx by learning and applying the methodologies of these enormous developing worldwide enterprises in East Coast territory, and if conceivable I might want to dissect our competi

Founding Fathers of Psychology Essay Example for Free

Establishing Fathers of Psychology Essay These four men that we are going to discuss are a portion of the, if not the most notable individuals in brain science. One created brain research as a way of thinking and distributed the principal book regarding the matter which opened the entryway for another to build up his hypotheses. A long time after the book came out another scholar was propelled to investigate the human psyche and this time with an all the more deductively basic brain and approach, there was a typical explanation individuals had issue, he simply was not positive what. This lead two of his understudies to proceed onward and one spotlight on the individual versus what the larger part has an issue with and ensured that treatment concentrated on them. The second glanced more top to bottom into what normally came into our psyche and how that influenced us and our turn of events. These were the non-official establishing fathers of brain science. This man never at any point rehearsed medication yet, subsequent to moving on from Harvard he proceeded to turn into a persuasive individual in brain research (Stone, 2000). Notwithstanding numerous different things that William James did to help with the field of brain science, particularly the mental parts of religion he additionally fiddled with the utilization of logical strategies to examine the generally immaculate profound and clairvoyant domain. He was additionally the first to battle for brain research to be perceived as a science, everybody after him has him to thank for the differentiation as a science (Croce, 2010). The manner in which he battled was only an increasingly unconventional method of going about it, he didn't care to be called analyst, in certainty he favored the term savant (Goodwin, 2008). He in the end built up a place that would turn into the establishment for the practical clinicians, this was known as sober mindedness. This depended on the conviction that an individual had power over what they do and life changes those encounters. This lead to a book that would change the manner in which individuals took a gander at brain research as something to pay attention to, the Principles of Psychology turned into the primary course reading type distribution regarding this matter which prompted individuals like Sigmund Freud and others to build up their hypotheses also. Freud is one of the most well known of all, when anybody considers brain science that has not glancing inside and out into its history will consistently consider Freud. Freud was not as far as possible individuals depict him either if something appeared to be unreasonably harming for his patient it was halted (Chessick, 2000). Analysis is difficult for everybody on the circumstance since it delves profound into what makes an individual demonstration the manner in which they do. Freud was said to have a special way to deal with his patients for his time span. He understood that when an individual discovers some new information or encounters something new it does without a doubt change something about that individual, he additionally realized that the past had something do with it and that there were layers of cognizance to an individual that has an impact too. He made them a piece of their treatment and tuned in to what they asked for from their treatment as opposed to directing to them what they ought to do to pass the time (Frank, 2008). He needed his patients to have the option to be free with themselves and learning their own impediments that may shield them from accomplishing something that they ought to do to pass the time. He needed them to be their own individual and not kept down by whatever has carried them to him. Freud himself concentrated more on doling out a general purpose behind individuals to carry on the manner in which they did which is the thing that affected his understudies to stretch out. Alfred Adler joined Freud’s psychoanalytic development in 1902, yet he left the gathering in 1911 due to diligent conflicts with Freudian hypothesis (Overholser, 2010). This methodology that Adler made was known as the Individualistic methodology this methodology centers exclusively around the patient and what encounters have molded them through an incredible span. This is one of the most inside and out approaches to psychoanalyze individuals, understanding the apparent blemish in Freud’s hypothesis; he investigated what made the individual interesting and how that changed their human experience. This improves the one so that in the long run that one will go out into society and become liable for themselves and each other as great individuals from it. Adler kept on accepting that Freud had made a point by glancing back at ones adolescence for answers but instead than concentrating on the sexual root to the issue, he concentrated on the sentiments that came out of a circumstance (Lafountain, 2009). For instance, on the off chance that one grew up reluctant to assume responsibility for circumstances since another person consistently did it for them, they could experience difficulty further down the road attempting to be accountable for themselves or others. In the wake of concentrating with Freud he proceeded to concentrate on how society influences an individual and how that individual capacities in the public eye. He accepted there were three things an individual expected to achieve in life to be a solid socially disapproved of individual. First is the errand of discovering how to endure, a vocation, keeping up ones house, the dependable things. Second is participating and being polite just as aware to society. Third are personal connections, having youngsters, companions, a mate. Each of the three of these were vital to being a typically working individual in the public arena (Lafountain, 2010). Fundamentally an individual is interesting in about all parts of their life and that should be considered in every single case from brain science to educating in light of the fact that not every person is going to fit together well. Carl Jung, as with Adler was roused and impacted by Freud in the early long stretches of his profession and similarly as with that came the inevitable difference and him heading out in his own direction. He reclassified some of terms that we are increasingly acquainted with today. He gave us the terms; contemplative person, outgoing individual, cognizant, oblivious, aggregate oblivious, persona, original, and all the more significantly mind. These were terms to streamline and group various procedures going on in the mind at some random second, one of the other increasingly significant and less obvious is the hypothesis of aggregate obviousness, this is the conviction that on the whole people have a mental information that they can draw on that is innate in our hereditary make-up (Carter, 2011). This was firmly trailed by the prime examples which without aggregate oblivious as a hypothesis would not be plausible, the originals are what those musings are comprised of in the aggregate oblivious, something like intrinsic nature that says we are characteristically expected to fear things that would do us hurt. Examining this brings out what is instinctual in people versus what is something that they know about doing, much like Freud’s subliminal idea hypothesis. Both concurred that there are things that are in people that are oblivious and simply occur and those should have been examined and comprehended too (Carter, 2010). Jungian adherents accepted that like Freud dreams had meaning yet in Jung’s school this permitted the individual examining the fantasies to free partner the significance dependent on their own insight into folklore and life versus what might be from the individual who is being broke down own life. The idea was that aggregate oblivious would make the examiner arrive at the right resolution dependent on oblivious contemplations going to and fro between the two. These four people molded brain research as what it is today, the two of them in a roundabout way and straightforwardly affected each other in any event, when some of them never met and history has reduced their achievements. James began everything with the psyche of a logician who appreciated the solidness of what science demonstrated yet in addition the secret of what it left open. Freud was a thinker who thought more as a researcher and hence opened that the cerebrum has shrouded data in it that should have been found to realize what makes an individual themselves. This drove Jung and Adler to take his beliefs and develop them where they concurred and where they oppose this idea. Without them brain research would not be the place it is today and you can see small amounts of what they contributed since its commencement. . References Carter, D. (2011). CARL JUNG IN THE TWENTY-FIRST CENTURY. Contemporary Review, 293(1703), 441. Chessick, R. D. (2000). Analysis at the Millennium. American Journal Of Psychotherapy, 54(3), 277. Croce, P. J. (2010). Coming to past Uncle William: A time of William James in principle and throughout everyday life. History Of Psychology, 13(4), 351-377. doi:10. 1037/a0021106 Frank, G. (2008). A reaction to The significance of Sigmund Freud for the 21st century. . Psychoanalytic Psychology, 25(2), 375-379. doi:10. 1037/0736-9735. 25. 2. 375 Goodwin, C. J. (2008). A History of Modern Psychology (third ed.). Hoboken, NJ: Wiley. Lafountain, R. (2009). Alfred Adlers Place in the Field of Psychology. Washington, District of Columbia, US: APA Division 1, Society for General Psychology. Overholser, J. C. (2010). Psychotherapy that endeavors to support social intrigue: A reproduced meet with Alfred Adler. Diary Of Psychotherapy Integration, 20(4), 347-363. doi:10. 1037/a0022033 Stone, A. A. (2000). Pictures in psychiatry: William James, 1842-1910. The American Journal of Psychiatry, 157(10), 1583-1583. Recovered from http://search. proquest. com/docview/220496188? accountid=35812.

Parents With ADHD Raising Children With ADHD

Parents With ADHD Raising Children With ADHD ADHD Parenting Print Parents and Children Who Both Have ADHD By Keath Low Keath Low, MA, is a therapist and clinical scientist with the Carolina Institute for Developmental Disabilities at the University of North Carolina. She specializes in treatment of ADD/ADHD. Learn about our editorial policy Keath Low Medically reviewed by Medically reviewed by Carly Snyder, MD on November 12, 2019 facebook twitter linkedin Carly Snyder, MD is a reproductive and perinatal psychiatrist who combines traditional psychiatry with integrative medicine-based treatments.   Learn about our Medical Review Board Carly Snyder, MD Updated on January 02, 2020 ADHD Overview Symptoms Causes Diagnosis Treatment Living With In Children Hero Images / Getty Images ADHD runs in families. That means that a child with ADHD is likely to have a mom or dad with the same disorder. Its critically important that the parentâ€"as well as the childâ€"be diagnosed and treated. Why Parenting Is so Tough When You and Your Child Have ADHD Parenting a child, any child, is a difficult task, to begin with. When you have a child with ADHD you are parenting a child who has greater demands, needs more involvement, and requires greater patience and understanding by the parent.? Add to the mix additional  siblings of the ADHD child  and conflicts, attention pulled in different directions, feelings of resentment by the child who requires less attentionâ€"all these factors combine to create a parenting role that can quickly become overwhelming. When a parent has undiagnosed ADHD, the difficulty level is ratcheted up even higher. If an ADHD parents child also has ADHD, there can often be significant dysfunction within the family. A parent with untreated ADHD will certainly have a hard time following through with treatment recommendations for the childâ€"keeping track of a child’s prescription, filling the prescription, administering the child’s medication on a regular schedule, keeping track of when the prescription needs refilling, creating routines and structure at home, implementing and following through with behavioral or reward programs at home, etc. If a parent has ADHD, that parent may also have a very difficult time being consistent with their child. Parenting skills will be affected by the parents own ADHD. Studies show that parents with ADHD tend to provide less supervision, have more difficulty keeping tabs on their children and knowing where they are and are less adept at creative problem-solving. If an issue or problem comes up, parents with ADHD tend to address it the same way again and again rather than thinking of other ways to handle the situation more effectively. It is often difficult for those with ADHD to be flexible in their approaches to parenting. Identifying and Treating Adult ADHD Is Key In the past, ADHD was mainly considered an academic or school issue for children. ADHD, however, is a 24 hour a day condition. It not only impairs school or work functioning it also can have a significant impact on families and social relationships. There is even a high incidence of divorce in families in which a member has ADHD. When a child is first diagnosed with ADHD, it is important to also screen the rest of the family to determine whether additional family members have ADHD. Once family members with ADHD are diagnosed, treatment can beginâ€"and other family members can begin to make sense of the challenges theyve been encountering. By properly identifying ADHD in individuals, treatment can be so much more effective and family life much more joyful.

Invisible Man By Ralph Ellison - 1586 Words

The Invisible Man spends the whole book, Invisible Man by Ralph Ellison, trying to come to terms with his identity, throughout the book he continues to learn and discover who he is. Ellison uses Invisible Man’s (IM’s) briefcase as a symbol of oppression throughout the novel, while he uses the briefcase to contrast IM’s sense of self-empowerment and his actuality of being used and controlled. Right after the invisible man’s story starts, he receives a briefcase after he is forced to participate in a fight. When he receives the briefcase he is in an uncomfortable situation and desperately wants to leave the area and forget that he had to fight and following that by giving a speech to privileged white people. He made a speech as a†¦show more content†¦This gives the briefcase meaning, although superficial, but because he got it out of a troublesome situation for himself and kept it to define himself and how he will act starts off his self-discovery in a negative light. The briefcase started a pattern of the Invisible man having supposed important roles in what he becomes a part of. When he goes to the college, he leads a white trustee around, which seems like a big honor and he is the one that receives this. Which leads to him realizing that it was not about him, it was about making a good impression for the college. When he enters the brotherhood it’ s not about him, the brotherhood uses him to wreck havoc. This is what his identity becomes based on starting with the briefcase and setting up how other people in the book use him throughout. The briefcase sets up his future throughout the book. Similarly, later on in the book when he acquires the doll that Clifton was doing a puppet show with he keeps it, resulting in a further attachment to pieces that seem to give him significance or identity. This doll connects the invisible man to Clifton, one of his best friends from the brotherhood. When the IM gets the doll he sees Clifton is performing with them after he left the brotherhood he goes to crush the doll because he is upset with what he has done but an old lady stops him and he takes the doll. â€Å"I dropped it in the pocket where I carried Brother Tarp s chain link and started after the vanishedShow MoreRelatedInvisible Man By Ralph Ellison1366 Words   |  6 Pagesfighter left standing, amidst unbridled carnage. The titular narrator of Ralph Ellison s novel Invisible Man, is no stranger to those experiences. In the beginning, he is forced to fight several other black boxers for the amusement of many heckling, white spectators. Through the imaginative use of object s, symbols, allusions, and the actions, thoughts, and purposes of the spectators, pugilists and risquà © entertainment, Ellison seeks to express a powerful image of American race relations and womenRead MoreInvisible, Invisible Man, By Ralph Ellison1994 Words   |  8 PagesInvisible Race and Gender in Invisible Man, by Ralph Ellison In Invisible Man by Ralph Ellison, the unnamed narrator shows us through the use motifs and symbols how racism and sexism negatively affect the social class and individual identity of the oppressed people. Throughout the novel, the African American narrator tells us the story of his journey to find success in life which is sabotaged by the white-dominated society in which he lives in. Along his journey, we are also shown how the patriarchyRead MoreInvisible Man By Ralph Ellison1246 Words   |  5 Pagesauthor of Invisible Man, Ralph Ellison, was born March 1st, 1914, and died April 16, 1994. He was born in Oklahoma City and named after Ralph Waldo Emerson, a famous journalist and poet. When Ellison was 3, his father died of a work-related accident, leaving his mother to care for him and his younger brother. As a young boy, he always wanted to major in music, and he went to Tuskegee University to become a composer and performer of music. The summer before his senior year in college, Ellison went toRead MoreThe Invisible Man By Ralph Ellison Essay2164 Words   |  9 Pagestrying to rebel against the status quo. Protest literature emerged from the Harlem Renaissance in the 1920’s to 1930’s. Protest literature is used to address real socio-political issues and express objections against them. In his novel, The Invisible Man, Ralph Ellison exposes the racism in society by focusing on the culture, in regards to the expected assimilation of African Americans and how the time period largely influenced the mistreatment of the African American population. He also uses symbolsRead MoreInvisible Man By Ralph Ellison1277 Words   |  6 PagesInvisible Man, by Ralph Ellison, is a story about a young African American man whose color renders him invisible. The theme of racism as a hurdle to individual identity is present throughout the story in a variety of examples. From the beginning of the novel the theme of identity is evident as the narrator states, †Å"All my life I had been looking for something, and everywhere I turned someone tried to tell me what I was† (Ellison, p. 1254). In the midst of living in a racist American society the speakersRead MoreInvisible Man By Ralph Ellison909 Words   |  4 PagesInvisible Man by Ralph Ellison is a novel which embodies the universal theme of self-discovery, of the search to figure out who one truly is in life which we all are embarked upon. Throughout the text, the narrator is constantly wondering about who he really is, and evaluating the different identities which he assumes for himself. He progresses from being a hopeful student with a bright future to being just another poor black laborer in New Your City to being a fairly well off spokesperson for aRead MoreThe Invisible Man By Ralph Ellison977 Words   |  4 PagesBook Review: Invisible Man Invisible Man is an American Literature novel published by Ralph Ellison in 1952. The novel traces the experiences of a young college black man growing up in Harlem, New York. Attempting to succeed in a predominantly white society, the narrator encounters shocks and disillusionments from being expelled from college to hiding in an underground hole to protect himself from the people above. He lives a repressed life as an â€Å"Invisible Man† for he believes that society ignoresRead MoreInvisible Man By Ralph Ellison1032 Words   |  5 Pageslike modern society some people leads, and others will follow. Subjects will conditionally generate their own ideas and realize these ideas rather than just be assigned tasks that question their beliefs. The author Ralph Ellison illustrates it best. Ellison’s realistic fiction Invisible Man perpetuates the manifestation of manipulation over the minorities in this society. As the narrator embraces every identity he has been given, h e starts to become more independent, and a leader in his community. Read MoreThe Invisible Man By Ralph Ellison3051 Words   |  13 Pagesportrayed through the narrator’s, the invisible man, journey through life. The problems with society are foreshadowed by the racism and the symbols of the color white presented in the paint plant. â€Å"The Invisible Man† by Ralph Ellison depicts the African Americans struggle to be viewed as an equal member of society through the narrators struggles through life to discover his individuality or place in society while the white man or the community conspires to â€Å"keep the black man down†. The story follows theRead MoreInvisible Man By Ralph Ellison1481 Words   |  6 PagesInvisible Man is a novel by Ralph Ellison, published in 1952. It addresses many of the social and intellectual issues facing African-Americans in the early twentieth century. This includes black nationalism, the relationship between black identity a nd Marxism, and the reformist racial policies of Booker T. Washington, as well as issues of individuality and personal identity. The grandson of slaves, Ralph Ellison was born in 1914 in Oklahoma City, Oklahoma, and was raised in Tulsa, Oklahoma. His

Rhinoceros Facts

There are five species of Rhinoceroses—Ceratotherium simum, Diceros bicornis, Rhinoceros unicornis, R. sondaicos, Dicerorhinus sumatrensis—and for the most part, they live in widely separated ranges. By most counts, there are less than 30,000 rhinoceroses alive today, a steep plunge in population for a mammal that has existed on the earth, in one form or another, for 50 million years. Fast Facts: Rhinoceros Scientific Name: Five species are Ceratotherium simum, Diceros bicornis, Rhinoceros unicornis, R. sondaicos, Dicerorhinus sumatrensisCommon Name: White, Black, Indian, Javan, SumatranBasic Animal Group: MammalSize: 4–15 feet tall, 7–15 feet long, depending on speciesWeight: 1,000–5,000 poundsLifespan: 10–45 yearsDiet:  HerbivoreHabitat: Subharan Africa, Southeast Asia, Indian subcontinentPopulation: 30,000Conservation Status: Three species are Critically Endangered (Javan, Sumatran, black), one is Vulnerable (Indian), one is Near Threatened (white) Description Rhinoceroses are perissodactyls, or odd-toed ungulates, a family of mammals characterized by their herbivorous diets, relatively simple stomachs, and ​an odd number of toes on their feet (one or three). The only other perissodactyls on earth today are horses, zebras, and donkeys (all belonging to genus Equus), and the strange, pig-like mammals known as tapirs.  Rhinoceroses are characterized by their large sizes, quadrupedal postures, and single or double  horns on the ends of their snouts—the name rhinoceros is Greek for nose horn. These horns probably evolved as a sexually selected characteristic—that is, males with bigger, more prominent horns were more successful with females during mating season. Considering how big they are, rhinoceroses have unusually small brains—no more than a pound and a half in the largest individuals, and about five times smaller than a comparably sized elephant. That is a common attribute in animals which have elaborate anti-predator defenses like body armor: their encephalization quotient (the relative size of an animals brain compared to the rest of its body) is low. WLDavies/Getty Images   Species There are five extant rhino species—the white rhinoceros, black rhinoceros, Indian rhinoceros, Javan rhinoceros, and Sumatran rhinoceros. The largest rhinoceros species, the white rhinoceros (Ceratotherium simum) consists of two subspecies—the southern white rhinoceros, which lives in the southernmost regions of Africa, and the northern white rhinoceros of central Africa. There are about 20,000 southern white rhinoceroses in the wild, the males of which weigh over two tons, but the northern white rhinoceros is on the brink of extinction, with a mere handful of individuals surviving in zoos and nature reserves. No one is quite sure why C. simum is called white—this may be a corruption of the Dutch word wijd, which means wide (as in widespread), or because its horn is lighter than that of other rhinoceros species. Actually brown or grey in color, the black rhinoceros (Diceros bicornis) used to be widespread across southern and central Africa, but today its numbers have dwindled to about half those of the southern white rhinoceros. (In Greek, bicornis means two-horned; an adult black rhinoceros has a larger horn toward the front of its snout, and a narrower one directly behind.) Black rhinoceros adults rarely exceed two tons in weight, and they browse on shrubs rather than grazing on grass like their white cousins. There used to be a bewildering number of black rhinoceros subspecies, but today the International Union for the Conservation of Nature recognizes only three, all of them seriously endangered. The Indian or greater one-horned rhinoceros, Rhinoceros unicornis, used to be thick on the ground in India and Pakistan until a combination of hunting and habitat destruction restricted its numbers to the puny 4,000 or so individuals alive today. Full-grown Indian rhinos weigh between three and four tons and are characterized by their long, thick, black horns, which are prized by unscrupulous poachers. On a historical note, the Indian rhinoceros was the first rhino to be seen in Europe, a single individual shipped to Lisbon in 1515. Plucked from its natural habitat, this unfortunate rhino quickly died, but not before it had been immortalized in a woodcut by Albrecht Durer, the sole reference point for European  enthusiasts until another Indian rhino arrived in England in 1683. One of the rarest mammals in the entire world, the Javan rhinoceros (Rhinoceros sondaicos) consists of a few dozen individuals living on the western edge of Java (the largest island in the Indonesian archipelago). This cousin of the Indian rhinoceros (same genus, different species) is slightly smaller, with a comparably smaller horn, which has not, sadly, prevented it from being hunted to near-extinction by poachers. The Javan rhinoceros used to be widespread across Indonesia and southeast Asia; one of the key factors in its decline was the Vietnam War, in which millions of acres of habitat were destroyed by incendiary bombing and poisoning of vegetation by the herbicide called Agent Orange. Also known as the hairy rhinoceros, the Sumatran rhinoceros (Dicerorhinus sumatrensis) is almost as endangered as the Javan rhinoceros, with which it once shared the same territory of Indonesia and Southeast Asia. Adults of this species rarely exceed 2,000 pounds in weight, making it the smallest living rhinoceros. Unfortunately, as with the Javan rhinoceros, the relatively short horn of the Sumatran rhinoceros hasnt spared it from the depredations of poachers: The powdered horn of a Sumatran rhino commands over $30,000 per kilogram on the black market. Not only is D. sumatrensis the smallest rhino, but its also the most mysterious. This is by far the most vocal rhino species and herd members communicate with one another via yelps, moans, and whistles. Habitat and Range Rhinoceroses are native to Subharan Africa, Southeast Asia, Indian subcontinent, depending on their species. They live in a variety of habitats, including tropical and subtropical grasslands, savannas and shrublands, tropical moist forests, and deserts and xeric shrublands. Diet Rhinos are all herbivores, but their diets depend on their habitat: Sumatran and Javan rhinos feed on tropical vegetation, including some fruits, while black rhinoceros are primarily browsers that feed on herbs and shrubs, and Indian rhinos feed on both grasses and aquatic plants. They require a great deal of time to forage and spend most of their active time doing that. Rhinos can be active day or night and generally regulate their activity depending on the weather. If its too hot or too cold, they will stay near water. Behavior If theres one place the average person does not want to be, its in the path of a stampeding rhino. When startled, this animal can hit top speeds of 30 miles per hour, and its not exactly equipped to stop on a dime (which may be one reason rhinos evolved their nasal horns as they can absorb unexpected impacts with stationary trees). Because rhinos are basically solitary animals, and because they have become so thin on the ground, its rare to see a true crash (as a group of rhinos is called), but this phenomenon has been known to occur around watering holes. Rhinos also have poorer eyesight than most animals, another reason not to linger in the path of a four-ton male on your next African safari. The closest rhinoceros bond is between a mother and her offspring. Bachelor rhinos congregate in small crashes of three to five, and sometimes as many as 10, to cooperate against predators. Rhinos may also gather around limited resources, water pools, wallows, feeding areas, and salt licks, always staying one body length apart. Reproduction and Offspring All rhinoceroses are polygamous and polyandrous—both sexes seek multiple mates. Courting and mating can occur at any time during the day. During courtship, males engage in mate-guarding behavior until the female is in full estrus and will permit males to approach her. Indian male rhinos whistle loudly to announce reproductive condition and location, six to 10 hours before breeding activity. Gestation takes 15–16 months, and by two months of age, calves are weaned and may be left alone while the female forager a few feet away. When separated temporarily, the female and her calves stay in contact through vocalizations. Calves suckle until the calf is two or the mother conceives again; they become completely independent at three years. Females become sexually mature at 5–7, and males at 10 years. Rhinos typically live between 10 and 45 years, depending on the species.   mantaphoto/Getty Images Evolutionary History Researchers trace the evolutionary lineage of modern rhinoceroses back 50 million years, to small, pig-sized ancestors that originated in Eurasia and later spread to North America. A good example is Menoceras, a tiny, four-footed plant-eater that sported a pair of small horns. The North American branch of this family went extinct about five million years ago, but rhinos continued to live in Europe until the end of the last Ice Age (at which point Coelodonta, also known as the woolly rhino, went extinct along with its fellow mammalian megafaunas like the woolly mammoth and the saber-toothed tiger). One recent rhinoceros ancestor, Elasmotherium, may even have inspired the unicorn myth, as its single, prominent horn struck awe in early human populations. Daniel Eskridge/Stocktrek Images/Getty Images Conservation Status All of the five species of rhinoceroses are listed as endangered or vulnerable ty the IUCN. Three are listed as Critically Endangered (Javan, Sumatran, and black rhinos); one is Vulnerable (Indian), and one is Near Threatened (white).   Ã‚  Klaus Vedfelt/Getty Images Threats Rhinoceroses have been continually driven relentlessly to the brink of extinction by human poachers. What these hunters are after is rhino horns, which, when ground up into powder, are valued in the east as aphrodisiacs (today, the largest market for powdered rhino horn is in Vietnam, as Chinese authorities have recently cracked down on this illicit trade). Whats ironic is that the horn of a rhinoceros is composed entirely of keratin, the same substance that makes up human hair and fingernails. Rather than continuing to drive these majestic animals into extinction, perhaps poachers can be convinced to grind up their toenail clippings and see if anyone notices the difference! Sources Emslie, R. Ceratotherium simum. The IUCN Red List of Threatened Species: e.T4185A16980466, 2012.---. Diceros bicornis. The IUCN Red List of Threatened Species: e.T6557A16980917, 2012.  Hutchins, M., and M. D. Kreger. Rhinoceros Behaviour: Implications for Captive Management and Conservation. International Zoo Yearbook 40.1 (2006): 150-73. Print.Talukdar, B.K. et al. Rhinoceros unicornis. The IUCN Red List of Threatened Species: e.T19496A8928657, 2008.  van Strien, N.J. et al. Rhinoceros sondaicus. The IUCN Red List of Threatened Species: e.T19495A8925965, 2008.van Strien, N.J., et al. Dicerorhinus sumatrensis. The IUCN Red List of Threatened Species: e.T6553A12787457, 2008.

Independent Behaviour Free Essays

iINDEPENDENT BEHAVIOUR (12 MARK ESSAY) Some reasons people show signs of independent behaviour (i. e. do not conform or obey) is influence by many factors, Gender being one of them. We will write a custom essay sample on Independent Behaviour or any similar topic only for you Order Now Neto carried out the same study as Asch, but this time all the participants were female (as in Asch’s study they were all male). In Asch’s study he found that 37% of the participants conformed, whereas Neto found that 59% conformed. However Asch’s study was criticized for lacking ecological validity and Neto’s study is a replication of Asch. As the participants were not in a natural situation Linz and Semykina took data from a survey of over 2,600 Russian employees between 2000 and 2003. They found that men are more likely to have internal Locus of Control and a need for challenge and women more likely to exhibit external locus of control and need for affiliation (belonging to a group). High Internal females earned more than external women. The fact there is a large sample size of 2600 means the findings are reliable, good sample size. However it can be argued that there is a potential cultural bias as the data was only taken from Russian employees. When Asch debriefed his participants, he found a common factor of confidence in the people who hadn’t conformed if someone felt confident in their judgments; they were more able to resist group pressure. This idea is supported by Perin and Spencer’s study. They replicated Asch’s study with engineering students. Conformity levels were much lower. Perin and Spencer attributed this to the fact that engineers had confidence in their skills in making accurate observations. How to cite Independent Behaviour, Papers

Recording, Analysing and using HR information free essay sample

It is extremely important for all organisations to record and store data for a number of reasons, one significant reason being to satisfy legal requirements. Government agencies such as HMRC, Department of Work Pensions and the Health Safety Executive to name but a few, can demand information from organisations at any time. Pay, tax and employee data needs to be accurately recorded and monitored by HR, in order to ensure employees are being treated fairly and organisations are compliant. Relevant legislation would include the National Minimum Wage Act 1998 with regard to pay, working hours are restricted under the Working Time regulations and safe working practices and conditions are outlined under the Health Safety at work Act 1974. Failure to comply with this legislation can lead to errors, accidents, increased absence, breakdown of the psychological contract, poor employee engagement, poor retention rates, a bad corporate reputation and can result in serious financial consequences such as fines, legal action or closure of business in extreme cases. Another reason that organisations collect HR data is for monitoring levels of employee sickness and absence. According to the CIPD’s 2013 Annual Survey Report on Absence Management, organisations reported employees absent between 6 and 8. 7 days each per annum at an average annual cost to the business of ? 595 per employee due to a lack of resource and productivity. As can be seen, hours lost due to sickness and absence can cost organisations a huge amount of time and money every year and attendance data collected can be used for Occupational Health investigations or capability reviews with the employee, especially should multiple instances of absence occur or a pattern emerges. Attendance data can also help to spot patterns and trends which can pinpoint other less obvious causes for absence. Poor line management, workplace bullying, poor motivation, a training need or a welfare issue can often be the cause of recurrent, short term absence and once highlighted, HR can intervene to offer practical support, advice and guidance to both employees and line managers in order to rectify these issues before they escalate further. Organisations store data collected in two ways. Before the technology boom in the late nineties, manual files (that are written or printed) were widely used but are now less popular, specially in large organisations that are heavily reliant upon technology. The benefits of manual files are that they are cheap to compile with little or no training required to extract information from them. However the downside being they take a large amount of space to store, they have little or no security and if they are destroyed or damaged, the information is permanently lost. Electronic storage on computer hard drives, shared drives, memory sticks, internet, intranet, dvd and so on is now the preferred method due to the many benefits. It is easier to input and update information on a computer, the information can be quickly distributed to a vast amount of recipients via email, can be easily manipulated and formatted for reporting purposes in various applications, doesn’t take up any physical office space and can be secured and protected via encryption programmes or passwords. Of course, data can be highly sensitive, confidential and valuable and therefore it is crucial organisations are responsible and compliant when collecting, storing and using this information. There are many pieces of legislation that relate to this such as Limitation Act 1980, The Data Protection Act 1998, Human Rights Act 1998, Regulation of Investigatory Powers Act 2000, Freedom of Information Act 2000, Anti-Terrorism, Crime and Security Act 2001 Part 11, Information and Consultation of Employees Regulations 2004, the Immigration, Asylum and Nationality Act 2006 and the UK Borders Act 2007. Two pieces of legislation in particular which are relevant to the everyday uses of HR data within organisations are the Data Protection Act 1998 (DPA) and Freedom of Information Act 2000 (FOIA). The DPA states that the processing of automated and manual data must comply with seven principles; the data must be used fairly and lawfully, used for limited, specifically stated purposes, used in a way that is relevant and not excessive, must be accurate and up to date, kept no longer than necessary, handled according to data protection rights, kept safe secure and must not be transferred outside the UK without adequate protection. There are guidelines produced by the Information Commissioner detailing the best practice for handling data and maintaining compliance in four areas; Recruitment Selection, Employment records, Monitoring at work and Information about workers health. Subject to certain exceptions (as detailed in Schedule 7 of the Data Protection Act 1998) employees have the right to access their records and also employers must seek the permission of he individual concerned before releasing any information to a 3rd party. Under the DPA, employers must keep certain data for specific statutory periods of time and once this has expired destruction of data must take place securely and effectively. The FOIA 2000 relates only to information gathered, stored and used in the Public sector (NHS, Government departments, Local Authorities, Police forces etc) and information held in the private sector on behalf of public organisations. It aims to improve accountability and provide transparency within organisations that spend public money. This gives the public the right to access all information including emails, documents, letters and notes, without any relation to themselves and without needing to provide a reason. The request can be denied only if it contravenes the Data Protection Act, harms national security or is not in the ‘public interest’ but even then a refusal has to be valid, reasonable, explained and an edited version released.

Battle Of The Beasts Essay Research Paper free essay sample

Battle Of The Animals Essay, Research Paper In 1954, with nil but their originative heads, the Toho Movie company produced the first elephantine monster film. Japan s Godzilla was brought to life. In 1998, with nil but Lucas Arts particular effects, and a name which guaranteed a blockbuster, the Centropolis Movie Company produced the All American Godzilla Flick. U.S.A. has eventually found its ain Godzilla. But is this new animal better than the Asiatic one? Despite the technological progresss and successful advertisement, the U.S. Godzilla has truly no comparing to the Nipponese one. Cinema has changed a batch in 45 old ages. In the times of King Kong and Dracula, # 8221 ; chilling # 8221 ; had a really important significance. Nowadays we are excessively smart for that. To do a batch of money, one might state a scientific discipline fiction film needs to look existent. In this regard, the American film is far better. The American audiences want to see an exciting film. We will write a custom essay sample on Battle Of The Beasts Essay Research Paper or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page In this regard besides, the American film is better. The film is besides, in most respects, a better film so any which came out in Japan. It is non nevertheless, Godzilla. The American monster doesn t even look like Godzilla. The visual aspect of Japan s Godzilla is better. The American Godzilla leans frontward at the hips when he walks. He has triangular bony home bases and a thin pointy tail. His oral cavity is like an iguana s. The Nipponese Godzilla is non a lizard. He is a mutated animal unlike any other. His bony home bases are really flimsy growings that are all over the topographic point. Godzilla, who was meant to mean atomic holocaust, besides closely resembles a human. In this manner, we can see a character out of him, non merely another elephantine lizard. His eyes are both pointed forward like a human, he walks unsloped like a human, and he has long forearms like a human. Godzilla doesn T have graduated tables, he has large perpendicular channels in a leathery tegument. He has a broad stance, muscular legs, and an look that merely takes some peoples breath off. And his illustriousness goes far beyond his expressions ; you can besides see it in his bosom. The Nipponese Godzilla is better because he has a psyche. He is powerful, yet sometimes defeated. He is an unstoppable force of nature, but besides a warrior. Godzilla is a elephantine monster, but he is besides a character. His face has looks, and he has a batch of motive. Such minute nsters are about non-existent in American civilization besides a few. King Kong, Frankenstein, and Dracula are all successful because the monster made sense. If the audience can t experience regretful or understanding for an evil animal, the animal has non done its occupation. Today s American audiences do non hold monsters with psyches. Our monster films are about the people in the movies, non the monsters. For illustration, Alien, Predator, Jurassic Park, Jaws. They are large computerized props. The audience has no emotion towards them. When they are on the screen sometimes we might desire them off. The American Godzilla is a lizard, nil more, even if it looks realistic. Last, the Nipponese Godzilla is better in the regard that it does non look existent. No Godzilla film has of all time been 100 % realistic. The U.S.A. Godzilla movie is realistic. When an audience tickers it, they believe their eyes. When you watch a Nipponese Godzilla film you can appreciate the fact that it is a film. It neer one time seems existent. The audience can play over the eldritch scientific discipline and rubber suits in their heads. Nipponese Godzilla films aren t existent, they re fictious ; beyond existent. They are like we imagine when we read a book. Most of all nevertheless, Japan s Godzilla is fun to watch, America s is non. America s Godzilla is merely a cool lizard from the find channel. We have possibly to many particular effects. Ever since Jurassic Parks improbably realistic dinosaurs, we are non as excited by the awful lizards we see and read about. When something fabulous becomes existent, it is no longer every bit interesting as it was earlier. One of the best Godzilla films of all time made would hold to be Godzilla V. King Kong. The conflict between the big E and west monster. There are a batch of good scenes in it, including when King Kong shoves a large tree down Godzilla s pharynx, and he coughs it back up. At the terminal King Kong and Godzilla are contending when they all of a sudden fall over the side of a drop. They fall in H2O, and King Kong is seen swimming to shore, presumptively stating Godzilla is dead. But is he? Remember he can swim underwater! Godzilla International Relations and Security Network t an animate being. He isn t a lizard or a firedrake or a dinosaur or even a cat in a gum elastic costume. Godzilla is a universe broad film fable. Truly, Godzilla is excessively large to melt off. Godzilla is truly one of a sort.

What Saddam was really thinkin essays

What Saddam was really thinkin essays The chosen supplementary text is an article titled WHAT SADDAM WAS REALLY THINKING written by Johanna McGeary. The source of the article is the Time magazine published on the 18th October 2004. The inner journey in this article is the decision journey that Saddam Hussein undertakes to become who he hoped to be and who he ended up to be. Saddam Husseins journey begins as he had always hoped to dictate how history would view him. In his mind, he was the successor to great Iraqi heroes like Nebuchadnezzar and Saladin... This shows that though the motivation of his idols, he has followed a life path experienced before by another person. (T)he dictators inner motivations and artful deceptions also motivated him through his journey. Saddams psychology powerfully shaped by a deprived and violent boyhood in a village and tribal society, especially by the strong influence of his xenophobic guardian uncle. This shows that at a young age, his life journey was already planned out for him by his uncle. Saddam was awed by science and impressed by the way technology conveyed military power. His mind was tempted to exploit the power of technology to achieve his goal to be a dictator. Saddam faced a critical decision to hide weapons of mass destruction and secretly maintain development programs, which meant that he could face tough sanctions from the U.N. However, Saddam made a calculated decision to destroy the evidence. Saddam has encountered an obstacle in his journey and has to find a new route to his destination. This is evident as he intended to resume developing weapons of mass destruction, however instead, (he) turned his cunning to sanctions busting. Saddam ordered the execution, which was the path he has chosen. However, this path has resulted in ...

Emergency Locator Transmitters (ELT) Essay Example | Topics and Well Written Essays - 2250 words

Emergency Locator Transmitters (ELT) - Essay Example Technological advances in design of all these modes of transportation have made them far safer than they have ever been since their inception. Aircraft are some of the most technologically advanced systems today, with some having the capacity to travel at the speed of sound, others capable of transcontinental flight, still others practically built to be fortresses in the sky. Ships have become more massive, or more streamlined. They have become floating island cities. Trains nowadays are technological marvels of speed and safety, carrying people from one place to another at a fraction of the time they used to. However, despite all these technological leaps, there have still been instances that disasters strike, and none of these modes of transportation have been spared from the rare occurrences of disaster. Most accidents are external in nature – lightning strikes an aircraft, an iceberg rams a ship, a bridge collapses under the weight of a train. Because of the ease at which these transportation agents bring people to their destinations, there has been a bigger volume of commuters in the world today than ever before. Therefore, there are far more people who start passengers and end up as victims of an accident, and the sad reality is, they could potentially be casualties in the final calculation. Recent accidents like that of Air France 447 where the debris of the ill-fated aircraft, an ultra-modern Airbus A330 jet carrying 228 passengers, have yet to be found, remind us of the importance of having equipment that allows for quick location of an accident. Casualties usually mount as more time passes from the time of the accident to the time rescue teams arrive. There has to be a way to decrease this time because every second literally means lives. To solve this problem, the distress radio beacons or emergency beacons were developed. They are basically tracking

Select one of your favorite brands that is involved in licensing Research Paper

Select one of your favorite brands that is involved in licensing. Write one page on why or why not it works for the brand - Research Paper Example 529). Acne Studios is a part of the Creative Collective Acne. The Studio was founded in the year 1996 in Stockholm, Sweden. Acne Studios is a fashion manufacturing brand that designs fashion apparels and jeans. The operations of Acne Studio are not only limited to Sweden. In fact, the operations are expanded across the world. In order to expand its operations, the company relies on licensing agreements. With the help of licensing agreements, the company has successfully expanded its operations in Europe and Asia. The Swedish company is also planning to expand its business in London, Paris, and Japan. The effectiveness of licensing for Acne Studios can be realized from the fact the company has successfully expanded its operations in 35 locations with the help of licensing agreements (Okonkwo pp. 353). Under the licensing agreement, the company sells its licenses to other companies. Those companies use the brand, design, and IP of the parent company. The licenses can be sold to several companies in the same market. The licensing agreements have also allowed Acne Studios to exercise control over how the brand is used. This has allowed the company to maintain the standard of its products (Okonkwo pp. 353). Hagedoorn, J., S. Lorenz-Orlean, and H. van Kranenburg. â€Å"Inter-firm Technology Transfer: Partnership-embedded Licensing or Standard Licensing Agreements?† Industrial and Corporate Change 18.3 (2008):

Receptor Activator of NK-κB for Tumor Cells

Receptor Activator of NK-ÃŽ ºB for Tumor Cells Introduction Cancers figure among the leading causes of death worldwide, accounting for 8.2 million deaths in 2012 .Lung, liver, stomach, colorectal and breast cancers cause the most cancer deaths each year. It is expected that annual cancer cases will rise from 14 million in 2012 to 22 within the next two decades Over the past several years, proteolytic cleavage and release of the ectodomain of membrane-bound proteins, also referred to as ectodomain shedding, has emerged as an important posttranslational regulatory mechanism for modifying the function of cell surface proteins. The cleavage of RANK should decrease its availability on osteoclasts and their precursors and simultaneously generate soluble decoy receptors that may inhibit the RANKL–RANK association and their by NFkB signaling[27] It was previously demonstrated that tumor cells express RANK and activate RANKL-RANK pathway. The RANK/RANKL axis emerges as a key regulator of breast cancer initiation, progression and metastasis. In addition, RANKL can protect breast cancer cells from apoptosis in response to DNA damage, as well as control the self-renewal and anchorage-independent growth of tumor initiating cells [13]. In a recent study it’s demonstrated that NK-ÃŽ ºB Signaling could be blocked by Enterokinase by cleavage of RANK (Receptor Activator of NK-ÃŽ ºB), suggests its possible application in treating diseases like Osteoporosis, cancer and diseases associated with bone loss [14]. Enterospeptidase could specifically cleave RANK on the sequence NEEDK was demonstrated by a surrogate peptide blocking assay [28] Enteropeptidase All animals need to digest exogenous macromolecules without destroying similar endogenous constituents. The regulation of digestive enzymes is, therefore, a fundamental requirement. Vertebrates have solved this problem, in part, by using a two-step enzymatic cascade to convert pancreatic zymogens to active enzymes in the lumen of the gut. Enteropeptidase (synonym: enterokinase [E.C.3.4.21.9]) is aglycoprotein enzymeof the digestive tract was discovered, by N. P. Schepovalnikow in 1899 in Russia (Walther 1900), as a element that is present in the duodenum and which can capable of activating pancreatic juice to digest fibrin. Enteropeptidase converts trypsinogen (a zymogen) convert into its active form trypsin by enteropeptidase, with selective cleavage of 6-Lys-|-Ile-7 bond which causes subsequent activation of digestive enzymes in pancreatic secretions. Subsequent activation of trypsin,it cleaves and activates other zymogens in pancreatic secretions,including chymotrypsinogen, proelastase, procarboxypeptidases, and some prolipases [1] In almost all vertebrate species, a short trypsinogen activation peptide is released that terminates with the sequence Asp-Asp-Asp-Asp-Lys(DDDK) (2). except for the similar sequences of trypsinogens from lungfish (IEEDK and LEDDK) and African clawed frog (FDDDK). The unique enteropeptidase substrate specificity has been exploited in protein engineering. The enteropepetidase recognizing sequence DDDDK↓I is often used in recombinant proteins that necessitate specific cleavage.Enteropeptidases specificity for its recognizing sequence makes it an ideal tool in biochemical applications; following protein purification enteropeptidase can cleave a fusion protein containing a C-terminal tag (such as poly-His) linked by this sequence to obtain the target protein 1.1 Enteropeptidase 1.1.1 Enteropeptidase expression: Enterokinase is believed to be Exclusively produced in the brush border by enterocytes and goblet cells of the duodenal mucosa, the enteropeptidase is ubiquitously distributed among vertebrates (Eggermont et al., 1971a,b; Rinderknecht, 1986; Mithoshi et al., 1990). It secreted in to the small intestine. It lacks in crypts but found substantialiy in villous enterocytes and maximal in the upper half of the villi, partucilarly on the brush border. enteropeptidaseis secreted from glands following the entry of swallowed food passing from the intestin. It resists destruction from the various enzymes in the small intestine but is destroyed by bacteria in the large intestine. It has been purified from several sources including porcine (Barrati et al., 1973), bovine (Anderson et al.; Liepnieks and Light, 1979), human (Kitamoto et al., 1995), murine (Yang et al., 1998) and rat intestine (Yahagi et al., 1996). In all cases the protease seems to be expressed as a single-chain precursor, which must be cleaved to achieve the native disulfide-linked heterodimer, in the case of human enteropeptidase consisting of an 86 kDa heavy chain and a 28 kDa light chain. Most of the structural elements are highly conserved, especially between human, bovine and porcine enteropeptidase, which share more than 80% identity in their amino acid sequences. The heavy chain, which contains various domains including membranespanning hydrophobic membrane anchors, several receptorlike motifs and up to 10 intramolecular disulfide bridges, is responsible for specific macromolecular substrate recognition (Lu et al., 1997; Mikhailova et al., 2007). The light chain is connected to the heavy chain via one disulfide e bridge and contains the classical catalytic triad (His57, Asp102 and Ser195 in chymotrypsin numbering) with up to four intramolecular  disulfide bridges. The small and catalytically active light chain offers especially high potential for biotechnological applications, and several attempts to understand and improve the functionality of this protease have been made (Lu et al., 1999; Liew et al., 2007; Shahravan et al., 2008). et al., 2004), Lu et al. (1997) have determined the crystal structure of a bovine light chain complex with a trypsinogen activation peptide analogue at a resolution of 2.3 A  ° . Human enteropeptidase has been recombinantly expressed in E.coli by Gasparian et al. (2003), although this resulted in insoluble aggregates and no crystal structure has yet been reported. The subsequent refolding via 6 M guanidinium chloride resulted in a total refolding yield of 2% after two cycles of renaturation. Enteropeptidase is serine protease it’s a heterodimer of a multidomain heavy chain and a catalytic light chain linked by a disulfide bond . Enteropeptidase anchored to intestinal brush border of duodenal enterocytes by a transmem brane segment in the a 82–140 kDa heavy chain and a 35–62 kDa light chain which consist the catalytic subunit. Replacement of the transmembrane domain by a cleavable signal peptide does not impair trypsinogen activation, indicating that membrane association is not  required for substrate recognition (Lu et al., 1997)..[3]Enteropeptidase is a part of the  chymotrypsin-group of serine proteases, and is structurally resemble to these proteins.[4] 1.1.2. Enteropeptidase gene ontology: In humans, PRSS7 gene (also known as ENTK) encodes enteropeptidase enzyme on chromosome 21q21. The gene spans ~90-kb in length and has 25 exons .Enteropeptidase mRNA is expressed majorly in the duodenum and, at poor levels, in the proximal section of jejunum. The human enteropeptidase cDNA open reading frame of encodes a 1019 amino acids Type II transmembrane protein with a calculated mass of 113kDa and with particularly 17 potential N-linked glycosylation sites. Few frameshift and nonsense mutations in this gene lead to a rare recessive condition characterized by severe failure to thrive in affected newborns, because of enteropeptidase deficiency.[6] Conversely, duodenopancreatic reflux of proteolytically active enteropeptidase may cause acute and chronic pancreatitis. 1.1.4 Structure Bovine enteropeptidase is synthesized as a single-chain precursor of 1035 amino acid residues (5) that appears to require proteolytic activation, suggesting that enteropeptidase may not be the â€Å"first† protease of the digestive hydrolase cascade. Active enteropeptidase has been cleaved after Arg-800 to produce a disulfide-linked heterodimer with an amino-terminal 120-kDa heavy chain and a 47-kDa light chain; 40% of the actual mass of these polypeptides is due to glycosylation (6, 7). The deduced amino acid sequences suggested that from a single-chain precursor, active two-chain enteropepetidase is derived. A potential sigal-anchor (SA) sequence near the amino terminus mediates membrane association of enter peptidase in intestine. The amino-terminal heavy chain consist the domains that are homologous to sections of the low density lipoprotein receptor(LDLR), two repeats found in complement serine proteases C1r and C1s, a MAM domain (so named for similar motifs first identified in the metalloprotease meprin, the Xenopus laevis neuronal recognition proteinA5, and protein-tyrosine phosphatase Mu), and a macrophage scavenger receptor cysteine-rich repeat ( MSCR). The light chain is a typical chymotrypsin-like serine protease. The activation cleavage site between the heavy and light chains has the sequence Val-Ser-Pro-Lys2Ile, which might be recognized by trypsin or other trypsin-like proteases. The carboxyl-terminal catalytic light chain is homologous to the class of trypsin-like serine proteases. Therefore, enteropeptidase is a mosaic protein with a complex evolutionary history. The enteropeptidase light chain amino acid sequence surrounding the amino terminus is ITPK-IVGG (human) or VSPK-IVGG (bovine), supporting that unidentified trypsin-like protease that cleaves Lys-fle bond to activate single-chain enteropeptidase.Therefore, enterokinase may not be the first enzyme of the cascade of intestinal digestive hydrolases. Enteropeptidase specificity for the DDDDK-I sequence of trpsinogen may be described by complementary basic-amino acid residues grouped in potential S2-S5 subsites. 1.1.3 enterokinase deficiency Therefore, enterokinase has been recognized to play a key role in regulating intestinal protein digestion. Certainly, patients with primary enterokinase deficiency, a genetic disorder with little or no enterokinase activity in the duodenum, have been reported to suffer from malabsorption and malnutrition, predominantly in infancy, and need to take drugs containing pancreatic enzyme mixture for recovery [2]. Because of its physiological importance, there have been a number of studies on the purification and characterization of enterokinase from various species [3-9] 1.1.5  Applications Entero kinase as Biotechnology tool Protein purification is frequently aided by use of protein tags: therefore, fusion proteins or chimeric proteins produced by recombinant DNA technology are utilized in the forefront of protein science research for applications as various as vaccine development, biochemical purification, immunodetection, functional genomics, analysis of protein trafficking, protein therapies, and analyses of protein– nucleic acid or protein–protein interactions (Beckwith 2000). In structural biology, where milligram amounts of homogeneous protein sample are generally required, the most common usefulness of chimeras participates in the separation of the fusion protein from the cell lysate by affinity chromatography. The most common affinity tags include E. coli thioredoxin (TRX; LaVallie et al. 2000),the hexa-histidine (His-tag; Bornhorst and Falke 2000), Schistosoma japonicum glutathione-S-transferase (GST; Smith 2000), Escherichia coli maltose-binding  protein (MBP; Sachdev and Chirgw in 2000)and avidin/streptavidin Strep tags (Skerra and Schmidt 2000). A number of other tags have also been developed (Stevens 2000). To produce crystals of a protein of interest to study its structure such as X-ray diffraction studies, bulky-affinity tags, such as MBP or GST, are generally removed using site-specific proteases in the engineered linker region, followed by purification to isolate the protein of interest from the affinity tag fusion protein and the used protease . However, certain problems may be faced during the cleavage step, including failure to recover active or structurally intact protein, high price of proteases (e.g., factor Xa and enterokinase),low yield, precipitation of the target protein or tedious optimization of cleavage conditions. Recent estimates indicate using a His-tag, maybe one-third to one-half of all proteins of prokaryotes cannot be overexpressed in bacteria as a soluble form (Edwards et al. 2000; Stevens 2000). This number is may higher for eukaryotic proteins, indicated by three latest high throughput studies (Braun et al. 2002; Hammarstrom et al. 2002; Shih et al. 2002), specifically bigger multi domain proteins. In E. coli, if the problem of insoluble expression of the His-tagged protein is faced, one or more of the following options are usually explored: varying culture growth conditions, chaperones co-expression, altering cell lines, or changing to a different affinity tag such as, TRX, MBP, GST or NusA Apart from affinity purification, the large-affinity tags offer numerous advantages. In a recent report, compared to the His-tag expression, TRX and MBP improved the solubility and expression of a set of 32, less than 20 kD small human of proteins in E. coli (Hammarstrom et al. 2002). For the sets of 32 larger human proteins (17–158kD; Braun et al. 2002) and 40 proteins of eukaryotes (9–100 kD; Shih et al. 2002), the large-affinity tags MBP (40 kD), NusA (54 kD), and GST (26 kD) were shown to be helpful in enhabcing the yield of soluble protein. One of the significant features of enteropeptidase is its exclusive substrate specificity, which recognizes Lys at P1 and a group of four Asp amino acid at P2-P5. Within this recognition sequence, a Lys or Arg residue at P1 and Lys residues at P2 and P3 seems to be highly essential for efficient cleavage (87). The structural factors for enteropeptidase substrate specificity have been contained in its catalytic light chain. There is a cluster of four conserved basic residues, R/KRRK at sites 96–99, which were assumed to interact with the acidic P2-P5 residues in the trypsinogen activation spot (74). Lys99 residue was found to have extensive contacts with the P2 and P4 Asp residues indicated in crystal structure of enteropeptidase light chain of bovine, (22). Lys99 amino acid is conserved in enteropeptidase from various species. Substitution of Lys99 with Alanine by site directed mutagenesis blocked enteropeptidase from activating trypsinogen. In compare, Lys96, Arg97 substituti on, and Arg98 residues on activity of bovine enteropeptidase had less significant effects (22). The exclusive enteropeptidase specificity for its substrate has been exploited in protein engineering. The DDDDK↓I sequence is ofen used in recombinant proteins where specific cleavage is required. Enteropeptidase has a high potential as a fusion protein cleavage reagent, because of high specificity for the amino-acid sequence (Asp) 4Lys,. An important benefit of enteropeptidase is that no crucial specificity residues are positioned on the C-terminal side of the scissile bond in its recognition site .Accordingly, when an affinity tag is linked to N-terminus the protein of interest,in maximum cases enteropeptidase is able to produce a digestion product with a native N-terminus. A study inspecting the significance of the P1–P5 positions concluded that the P1 lysine was the most important specificity element, followed by the aspartate amino acids in the P2, P3, P5 and P4 positions, respectively, with the latter position donating very little to specificity In an effort to improve the utility of enteropeptidase for processing fusion proteins and to better understand its structure and function Activating Proteses The N-terminal pro-sequence of proteases which must be cleaved prior to activation can be mutated to enable activation with enteropeptidase.[7] Target for Obesity Treatment Congenital enteropeptidase deficiency now days attracted attention as a novel target for obesity Treatment, among the identified genetic diseases related with starvation human phenotype, Obesity is a complex metabolic disorder, in which various environmental factors and several genes are involved [1], [2]. Previous research targeting to develop drugs for treatment of obesity and type II diabetes has targeted genes that are linked with a fat human phenotype. Certainly, substantial work has been dedicated to participates developing drugs against these so called â€Å"obesity genes,† all of which are, directly or indirectly, in energy controlling; e.g., control of appetite, energy generation; carbohydrate and protein metabolisms, satiety, or thermogenesis, fatty acid, etc. [3], [4]. However, in humans, obesity is hardly attributable to the role of a single gene (wild or mutated). Additionally, the high redundancy of genes participates in energy management makes it unlikely that obesity will ever be controlled by affecting just one gene The foregoing proposes that EP activity may aid as selective and competent target for metabolic disorders treatment. While complete of blocking enteropeptidase would cause the unwanted side effects observed in patients affected by CEP, partial inhibition should reduce the efficacy of energy absorption through the gastrointestinal (GI) tract. A 15–20% decrease in the daily absorption of deriving energy from both fatty acids and proteins should have a major influence on long-term weight controlling, and it should be an extra effective weight-control measure than a treatment centered only on pancreatic lipase inhibitors such as Alli or Xenical. It should be noted that these drugs endorse the buildup of undigested lipids in the intestinal tract, causing in leaky stool and diarrhea. An additional benefit of partial enteropeptidase inhibition is that the combination of undigested proteins and lipids would be more reliable than just fat, debatably fading or suppressing the above unpl easant effects.

Earthworm Biodiversity in an Arid Region of Rajasthan, India

Among the soil fauna, earthworms have an important role to improve soil texture. The soil texture plays an important role in water holding capacity. Earthworms have an ability to enhance soil characteristics. It contributes to the breakdown of organic matter and release plant nutrients (Edwards and Bohlen, 1996). Earthworms are also considered as useful indicator of the health of soil ecosystem (Edwards and Bohlen, 1992) as to their role in soil fertility through fragmentation and mixed up the soil with mineral particle, enhancing microbial activity to breakdown plant organic matter.The contribution of earthworms in soil turnover, structure formation and serve as a fertility enhancer in different way. Earthworms are useful in land improvement and organic waste management (Edwards and Baker, 1992; Lavelle and Martin, 1992; Johnson, 1997; Villenave et al. , 1999). The distribution and population density of various earthworm species have been correlated with soil type and agriculture la nd use (Haynes et al. , 2003; Sbrina et al. , 2009). The biodiversity of earthworms is influenced by physical, chemical and biological properties of soil and climatic conditions of habitats.Earthworm’s biodiversity is directly affected by soil characteristics (Edwards and Lofty, 1977). These community influencing factors are soil pH, organic matter, nitrogen, C/N ratio, soil moisture and soil texture. Biodiversity is counted as human resources (Heywood, 1996). Recently, many biologists studied the biodiversity and distribution of earthworms in the different parts of the world (Blakemore, 2000, 2002, 2003; Change and Chen, 2004,2005; Blakemore et al. ,2006; Sautter et al. , 2006; Ghafoor et al. , 2008).Present study was done in Bikaner district, which is located in Thar desert of Rajasthan ranging 28. 01 ° N 73. 19 ° E. . The average rain fall in this area is 10† to 15† only. Therefore, climatic conditions are adverse for organisms. Most of its area is irrigate d with tube wells and Indira Gandhi canal. Due to adverse conditions from a long period, there is still a few information about biodiversity and habitats. The present study will revealed new basic information for further research on earthworms and its ecology and application of earthworms in agriculture sector.

Components of American Economic Growth between 1820-1860 Essay

Despite the thrust of the Jeffersonians towards agrarian reliance and its expansion, by 1820 however, the American economy was moving more towards industry and technology. American economic growth was â€Å"linked to and influenced by events elsewhere in the world particularly in Great Britain which was the home of the Industrial Revolution. † The advance of industrialization fueled economic growth. There were the technological innovations that allowed for the increase in production. With the factory system, we see for the first time that goods were produced faster than the population could grow. It was fortunate that the United States has abundant supply of natural resources or raw materials necessary for the production of goods. Moreover, with increasing European migration to the Americas, the demand for additional workers necessary for economic expansion was met. There were other factors that contributed to this continued development. Improved transportation played a key role. There was a time that the Federalists and anti-Federalists were arguing against the viability and management of a continued expansion. This has now been rendered moot as canal-building projects in the 1820’s and 1830’s and the construction of the railroads which dramatically transformed this situation. Moreover, it was also instrumental in bringing about economic and geographic expansion. â€Å"Canals and railroads provided farmers, merchants and manufacturers with cheap and reliable access to markets and goods and encouraged Americans to settle the frontier and cultivate virgin lands. † Before the canals, the freight rates were prohibitive and it was not financially viable to produce more that the local market. Then, seeing Britain’s success with the steam-powered railways, the U. S. followed suit with the construction of its railroads which does not freeze over unlike canals. With railroad expansion, the U. S. experiences faster economic growth. â€Å"Goods, people, commercial information flowed even more predictably, rapidly and cheaply. † As well, improved transportation â€Å"stimulated agricultural expansion and regional specialization. † Rather than produce diverse products for local consumption, they can just import staples from other regions and focus instead on producing products that are high yield and suitable to their soil and climate. Hence, by the late 1830’s â€Å"the old Northwest had become the country’s granary while New England farmers turned to dairy products. † Then there was the infusion of capital from foreign investors and from the fast-growing merchant class. There were new investments and the rise of new enterprise. While cities had the major share of factory concentration which led to urbanization, there were one or two factories as well which located in the smaller towns. Local and state governments did their share in encouraging entrepreneurship by passing laws of incorporation, granting tax breaks or monopolistic control, underwriting bonds for improvement projects and provision of loans. Judicial decisions also created ownership and concept of property rights and the binding nature of contracts. There was also the rapid spread of education that fostered innovation, productivity, discipline and skills development. Then, there were the intangible factors. The Americans in this era were simply thinking differently. The entrepreneurial outlook was present and there was a constant drive for change and improvement. Work Cited â€Å"Economic Transformations in the Northeast and the Old Northwest. † Name of Book. XXX ed. Year Published.

The Prison System Is Set Up To House Inmates Based On Their

The prison system is set up to house inmates based on their gender; male or female. But, society has evolved and the standard binary system does not apply to most people today, so where does this leave the transgender inmates? Trans inmates, regardless of whether they have been taking hormones before their sentence or not, are housed in the facility that matches their biological gender rather than their identified gender. Transgender inmates, especially trans women, face many obstacles including access health care, violent attacks, and sexual assault, however, if a trans inmate has received sex-reassignment surgery, they will be housed with their identified gender meaning that prisons are housing inmates based on genitals rather than†¦show more content†¦In step two, the trans person must openly live as their identified gender for about two years which includes dressing, speaking and operating like their identified gender, beginning a hormone treatment and sometimes cosmetic surgery, at their own cost, if desired. There are many transgender people who are content with living the rest of their lives in step two, but if a medical professional deems it medically necessary for the trans person’s health and they (the trans person) is confident in themselves, the third and final step is sex-reassignment surgery. Per Agbemenu, SRS consists of â€Å"vaginoplasty for trans females and phalloplasty for trans males†. Now, with a better understanding of gender dysphoria and sex-reassignment surgery, one may better understand opposing arguments. The pro-SRS party argues that the denial of sex-reassignment surgery to trans inmates, who are in medical need of the procedure, is a direct violation of the inmates’ eighth amendment rights. The Eight Amendment reserves all inmates the right to adequate medical care and the protection from â€Å"cruel and unusual punishment†. Inmates who suffer from gender dysphoria can suffer from symptoms such as depression, anxiety, and even self-mutilation if they do not receive proper treatment in a timely manner and the prison systems have exploited this greatly. There have been cases where trans inmates do end upShow MoreRelatedPrison Systems Essay1251 Words   |  6 PagesPrison Systems Comparison Essay Alexa Werstiuk CJA/234 Introduction State Prison History The state prisons today were founded on the basis of the 1700s to 1800’s during the Age of Enlightenment. The English correctional facility referred to as a â€Å"gaol,† commonly known as a jail. They housed men, women, children, the mentally ill along with the civil and criminals. The individuals suffered from idleness, diseases, despair and malnutrition. The gaols were maintained by local authoritiesRead More†¢ An explanation of factors influencing growth in jails, state prisons, and federal prisons772 Words   |  4 PagesJail and Prisons Paper Toshua White CJA/ 234 February 05, 2014 Mr. James Leonard Jail and Prisons Paper In this paper we will discuss some descriptions of jail’s place in corrections and its role throughout history on most of these offenses come with a sentence of a year or less and anyone with over a year sentence is usually sent to a prison facility (Seiter, 2011). On the other hand, prisons have an ample amount of time to work with, rehabilitate, and reform offenders. Prisons do thisRead MoreA World Apart: a Comparison of the Italian Prison System to Ours1201 Words   |  5 Pagesof phoenix | A World Apart | A Comparison of the Italian Prison System to Ours | | Matthew Kramer | 4/23/2011 | | The Italian correctional system although much older than the American system are very comparable to each other. Both have come from fledgling institutions in the past that have both evolved because of officials in higher positions as well as concerned citizens that have voiced their opinions on how inmates are treated and how they are housed during their sentences.Read MoreThe Criminal Justice System And The United States Essay1445 Words   |  6 PagesCriminal Justice System has made many changes since it first started in the 17th Century. The Criminal Justice System first began in the United States during the colonial times, when the colonist had to follow the rules of the British. During the Colonial times, the Criminal Justices System was not as fair as our current system is today, which meant a lot of people did not have liberties and were ultimately treated unfairly. Times have definitely changed for the Criminal Justice System and for the UnitedRead MoreJails, Prisons and Co mmunity Based Corrections1210 Words   |  5 PagesJails, Prisons and Community based Corrections Anthony Canez CJA/204 June 27, 2013 Robin Downey Jails, Prisons and Community based Corrections In this essay I will attempt to explain and discuss probation and how it compares to other forms of sentencing, the types of prison, the origins of rehabilitation in prisons, parole and how it differs from mandatory release and finally options of community corrections. Ending the essay will be a critique on the current rehabilitation options. The historyRead MoreU.S. Prison Costs Essay example1610 Words   |  7 PagesU.S. Prison Costs After reading the essay, â€Å"A Homemade Education,† an autobiography of Malcolm X, I became quite curious about how many dollars America spends toward the prison system and how it affects our society. The autobiography itself covers how Malcolm X gained a homemade education simply by reading books while serving time in prison. He claimed, â€Å"I don’t think anybody ever got more out of going to prison than I did†¦prison enabled me to study far more intensively†¦sometimes as muchRead MoreSentencing And Correctional Policies During The United States Essay1730 Words   |  7 Pagesand assume we have better prisons, a further look into Germany s prison shows us just how much better they are in prison styles and comfort for the inmates. Going further into I will discuss crime rates, incarceration rates and how different the policies and sentencing procedures really differ and how the outcome and recidivism of the inmate is between the United States and G ermany. Crime rates as of 2015 in the United States according to Spies, violent crime did go up 3.8 percent after a twoRead MoreJails and Prison Comparison1067 Words   |  5 PagesJails and Prisons Comparison University of Phoenix CJA/234 Ms. Pamela Collinshill June 25, 2013 Introduction: For more than two hundred years the United States has used incarceration to punish any and all criminals. Jails and prisons are the institutions that judges send criminals to so they can serve time depending on the seriousness of the crime that the individual has committed. Being incarcerated is the humane form of punishment that isRead MoreState and Federal objectives of punishment Essay1092 Words   |  5 PagesFor centuries governments have acted on behalf of society removing and punishing criminals with the goal of protecting its citizens. Criminals were arrested and locked-up in jails awaiting their sentencing. Once sentenced, they were publically humiliated, tortured, or killed. Early forms punishments were cruel and mostly focused on retribution. State and Federal objectives of punishment Today punishment is the most dominant correctional goal of both the state and federal government in responseRead MoreWhat Happens Behind Prison Doors? Essay1539 Words   |  7 Pagesyou ever wondered what happens behind prison doors? Prisons are defined as a correctional institution where persons are confined while on trial or for punishment. A prison is also referred to a place of detention. Embodiment of the United States is a concrete power under the Constitution of the United States, which means that prisons are under authority of both the federal and state governments. Different United State prisons contain different prisoners based on the crime or felony committed. Security